Calgranulin is an S-100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils. Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.
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